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Measurement of Priority Outcome Variables in Dermatologic Surgery (IMPROVED)

Condition

cutaneous squamous cell carcinoma (cSCC)

Background

There is a lack of consensus on treatment recommendations for cutaneous squamous cell carcinomas. This is due to a lack a standardized set of outcomes, which makes it is difficult to truly assess and compare the efficacy of various therapies and interventions.

Scope of the intended COS

  • Study types: e.g. RCTs: RCTs or Controlled Clinical Trials
  • Region, e.g. global scope: Global scope

Methods

We aim to develop a core outcome set by (1) identifying all current outcomes from a systematic review of literature; (2) involving other stakeholder groups such as other clinicians, and regulators to participate in identifying additional outcomes; (3) conducting Delphi consensus exercises on the identified outcomes; (4) presenting all results from the Delphi exercises during a face-to-face (if possible) consensus meeting to vote and agree upon a core set of outcomes important for cSCC research.

Involvement of stakeholders

Stakeholders, or those invested in the development of a core outcome set, will also be included in the decision process, along with patients. Dermatologists, and industry scientists associated with drugs and devices for treatments of cSCC are potential members that can provide input regarding what outcomes they feel should be represented. Nurses, physician assistants, and other health care practitioners may be included as well to enhance further discussion.

Current status

Completed systematic review of literature, Delphi consensus, and Consensus meeting. Publication submitted.

Funding

Departmental research funds

Involved Countries

USA, UK, Canada, Australia, Italy, France, Spain, Brazil

Date of updates

  • 28/07/2020

Lead

  • Murad Alam, MD

Project team members

Steering Committee:

  • Murad Alam, MD
  • Joseph F. Sobanko, MD
  • Ian A. Maher, MD
  • Todd V. Cartee, MD

Responsible member of Methods group (as assigned by CS-COUSIN)

  • Jamie Kirkham, PhD

Contact

Murad Alam, MD (m-alam@northwestern.edu)

Published references

1. Schlessinger DI, Iyengar S, Yanes AF, Chiren SG, Godinez-Puig V, Chen BR, Kurta AO, Schmitt J, Deckert S, Furlan KC, Poon E, Cartee TV, Maher IA, Alam M, Sobanko JF. Development of a core outcome set for clinical trials in squamous cell carcinoma: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey. Trials. Jul 12 2017;18doi:ARTN 321
10.1186/s13063-017-2069-2